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In a published paper, Nichols had reported that rats that had been trained to press a lever when administered MDMA also hit the button when given MTA. That apparently was enough to catch the attention of a rogue chemist who synthesized the drug, rechristened it Flatliners, and sold it in the Netherlands. The choice of name was a morbid harbinger. By 2002 Flatliners had killed at least six people. Nichols believes they died from an overdose of the neurotransmitter serotonin. Flatliners, it turns out, does not release the dopamine and norepinephrine that account for much of ecstasys euphoric effects, but, like ecstasy, it does release massive doses of serotonin and interferes with the bodys efforts to break it down. That apparently accounted for the reaction Nichols recorded in rats, which recognized the serotonin rush caused by MDMA.


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